TANIGUCHI Laboratory - Kyoto University /RIKEN

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Pursuing next-generation life/medical science through exhaustive analyses of the cell

Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University

Graduate School of Biostudies, Kyoto University

Laboratory for Cell Systems Control, RIKEN Center for Biosystems Dynamics Research

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Biological functions such as cellular differentiation are often regulated by vast numbers of molecules. Elucidating the general principles behind the organization of these complex molecular environments is a critical challenge.

Our laboratory addresses this challenge by developing new technologies for the large-scale characterization and manipulation of intracellular molecular activities. By integrating knowledge from multiple academic fields, including biology, chemistry, physics, medicine, and informatics, we aim to understand, predict, and control intracellular molecular interactions.

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Research

Elucidating novel aspects of life using innovative new technologies
Continued progress in modern life science is supported by the development of new technologies such as genome sequencing and mass spectrometry. Our laboratory aims to enhance this progress by uniting various academic fields to create breakthrough new technologies. We work with the following array of technologies and fields as potential elements of the new technologies as examples.
Next-generation sequencing
A technique for deciphering the sequences of millions to hundreds of millions of DNA fragments in parallel. It can be used to analyze genome sequences and gene expression levels in various biological organisms.
Multi-omics analysis
A comprehensive and integrated analysis for various species of bio-molecules including DNA, RNA, proteins and metabolites in a cell or tissue.
Molecular dynamics simulation
A method for predicting and simulating motions of molecules by repeatedly solving the Newton's equation of motion with a computer to calculate physical forces acting among atoms.
Optical microscopy
A method to observe detailed structures in a sample with a light. It can be used to selectively detect specific species of molecules with fluorescent probes and to capture their spatial distributions at single-molecule level.
Single cell analysis
An analysis to examine characteristics of each single cell, aiming at a bottom-up understanding of the life.
Lithography
A technology to construct micro- or nano-structures on a substrate using a light or electron beam.
Large-scale genetic recombination
A technique for altering various features of biological organisms by rewriting their genome sequences on a large scale.
Genome editing
A technique to efficiently rewrite genome sequences at any loci using a site-specific nucleic acid-degrading enzyme.
Cell differentiation technique
A technique for transforming undifferentiated cells into functionalized cells through physical stimulations, growth factor regulations, gene introduction or compound treatments.
High-throughput measurement
A method for measuring large quantities of samples using automated systems/robots to rapidly find conditions that exhibit characteristic features.
Software development
An approach to build a computational platform to analyze large amounts of datasets such as images and sequence sequences or to carry out efficient and large-scale simulations.
Bioinformatics
A field aiming at analyzing information on numerous species of bio-molecules such as DNA, RNA and protein using informatic/statistical methods to find underlying mechanisms or global rules.
Machine learning
A method for data prediction and analysis based on a computer algorithm to discover features or patterns hidden in a vast amount of datasets.
Physical modeling
An approach for logical understanding and prediction of complex biological phenomena by formulating quantitative relationships among multiple parameters or their dependence on environments.
Research theme
Elucidating the working principles of the genome
Our laboratory aims to understand the working principles of the genome by investigating its molecular-level architecture from the standpoints of chemistry and physics.
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Research theme
Understanding the constitutional principles of cellular systems
Our laboratory is developing techniques to quantify all intracellular proteins (the proteome) under various physiological conditions, which will allow us to determine the control logic of the proteome.
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Research theme
New principles and methods in disease diagnosis
Our laboratory is pursuing various technological approaches aimed at accurately capturing and manipulating the physiological states of living organisms, including humans.
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News

  • Feb 24, 2023
    Award
    Prof. Taniguchi received the 15th Nakatani Foundation Incentive Award
  • Feb 01, 2023
    Award
    Prof. Taniguchi was awarded the 5th Teruo Hiruma Optical Science Award.
  • Jun 09, 2022
    News
    An interview article with Dr. Kim was posted on the RIKEN BDR website.
  • May 23, 2022
    News
    Dr. Hidaka received the scientific research fund, Grant-in-Aid for Early-Career Scientists, 2022.
  • May 23, 2022
    News
    Dr. Kim received the scientific research fund, Grant-in-Aid for Early-Career Scientists, 2022.
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Kyoto University

Kyoto University Institute for Advanced Study

Institute for Integrated Cell-Material Sciences

Graduate School of BIOSTUDIES

RIKEN

RIKEN Center for Biosystems Dynamics Research

RIKEN Center for Biosystems Dynamics Research

Graduate School of Frontier Biosciences, Osaka University

TANIGUCHI Laboratory - Kyoto University /RIKEN
Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University
Graduate School of Biostudies, Kyoto University
Laboratory for Cell Systems Control, RIKEN Center for Biosystems Dynamics Research
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Email

ytaniguchi [at] icems.kyoto-u.ac.jp

Kyoto University

Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University
KUIAS/iCeMS Research Building
Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan
TEL: +81-075-753-9842

RIKEN

Laboratory for Cell Systems Control, RIKEN Center for Biosystems Dynamics Research
Quantitative Biology Buildings
6-2-3 Furuedai, Suita, Osaka 565-0874, Japan
TEL: +81-06-6155-0114